LSPR Biosensors

Active thin-film sensors enabling remarkable detection across industry sectors

LamdaGen offers its patented nano-structured metallic thin-film sensors as powerful biosensors for precise and rapid diagnostic applications in areas such as human and animal health, food & beverage safety, water and environmental contaminant monitoring. The company’s biosensors are also used as consumables for its label-free LightPath™ platform.

LamdaGen’s nano-structured thin-films are grown on a micron to millimeter scale using the Company’s patented processes. The highly scalable manufacturing process provides exquisite architectural control over the nano-structured films’ morphology thereby allowing fine tuning of the desired resonance condition for the plasmon polaritons. As a result, these patented films have a far narrower plasmon peak than colloidal particles which enables significant sensitivity enhancement. Additionally, the sensor films have a pure, rich and characteristically intense ruby color which allows for precise digital imaging.

Beyond the sensors’ significant optical features, the Company’s nano-structured gold films have other advantages including:

  • Compatibility with:
    • a wide range of solvents (DMSO, alcohols, aqueous buffers)
    • broad pH environments (e.g. 1M HCl – 1M NaOH)
    • very high ionic strengths (> 1M NaCl)
    • temperatures >80o C
    • various matrices including cell lysates, supernatants, sera, whole blood, urine, saliva, tears and milk
  • Possess a surface ready for the formation of Self-Assembled Monolayers (SAM), silanization or other coatings needed for further functionalization
  • The films can be functionalized through conventional surface chemistries
    • Covalent carboxyl, amine or thiol-based chemistry
    • Protein A/G, Streptavidin
    • Physisorption
    • Dextrans and others
    • Proprietary functionalization systems

The films are stable, easy to handle and can be grown on various surfaces (e.g. glass, polymerics, stainless steel, ceramics, etc.) and in any shape or dimension. The sensors are also cost effective, scalable and highly reproducible.

These patented surfaces form powerful biosensors with quantitative detection limits (~0.05 ng/mL or ~50PPT, model dependent) and offer rapid real-time detection (10-20 minutes) of biomolecular interactions through precise monitoring of light interacting with the nano-structured smart surfaces.

LamdaGen provides a wide range of standard sized biosensors as well as customized sensor designs for integration with existing product applications or next-generation products in development.

In general, LamdaGen’s biosensors offer remarkable performance coupled with extraordinary design and sizing flexibility. Several systems including single, multiplexed and/or throughput configurations as shown on the right.

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Frequently Asked Questions

FAQ: How reproducible are LamdaGen’s LSPR biosensors?

At LamdaGen’s nano-fabrication facility, the Company’s manufacturing processes have been diligently altered and refined over the years into very specific protocols and procedures that ensure precise reproducibility of its nano-structured surfaces – sensor to sensor, chip to chip, batch to batch and month to month. Additionally, due the fact that the biosensors are manufactured as metallic thin-films, the stability of LamdaGen biosensors has been evidenced to exceed four years.

FAQ: Can LamdaGen’s LSPR films be grown on differing substrate materials?

LamdaGen’s manufacturing processes and protocols are highly controllable, robust and reproducible.  By precisely altering certain conditions, the Company has learned how to “grow” its LSPR continuous metallic films on almost any surface.  Presently we are manufacturing for end users, including academic researchers, on many polymers, ceramics, as well as stainless and glass for a multiplicity of uses.  Recently we are also growing films on selected membranes and filters for use in the area of diagnostics. Contact us for custom requests.

FAQ: Are LamdaGen’s LSPR biosensors scalable for throughput?

LamdaGen’s LSPR biosensors are a continuous metallic thin film which is characterized by a variety of unique physical, optical, and electrical properties that can be precisely controlled and tuned during manufacture for specific uses. These patented nano-structured films are “grown” on most any surface (glass-polymers-stainless-ceramic etc) and to nearly any size, shape or geometry, again depending on need or use. Due to this flexibility, the Company’s robust biosensors are also quite scalable.