Label Free Detection

LSPR Label-Free Detection

LightPath system utilizes LamdaGen’s powerful LSPR (localized surface plasmon resonance) technology to analyze biomolecular interactions in real time with label free detection.

LamdaGen’s LSPR platform is based upon its nano-structured metallic thin-film surfaces. These patented surfaces form a powerful biosensor to detect real-time biomolecular interactions through precise monitoring of wavelength change at its surface.

LamdaGen’s LSPR technology requires a light source and its nano-structured LSPR biochip. There is no need for adaptive elements to couple the light to the localized plasmons of the nano-structured surface. Among the broad spectrum of light, one wavelength resonantly couples to the localized plasmons on the biochip surface and is dominantly absorbed.

LSPR Label Free Technology Advantages

  • Real-time data
  • Media friendly & negligible bulk effect
  • Highly reproducible
  • Temperature tolerant
  • Cost effective
  • Scalable for high throughput
  • High sensitivity

A number of direct label-free formats can be performed and monitored in real-time with LamdaGen’s biosensing technologies. Two simple examples are illustrated below.


LamdaGen’s LightPath S4 performs precise label-free real-time protein monitoring and analysis.