LSPR Technology Overview
LamdaGen’s Localized Surface Plasmon Resonance (LSPR) platform is based upon its nano-structured metallic thin-film surfaces. These patented surfaces form a powerful biosensor to detect real-time biomolecular interactions through precise monitoring of light interacting with the LSPR active surface.
LSPR has significant performance advantages over existing diagnostic technologies, including speed, simplicity and sensitivity. LamdaGen is the first company to commercialize LSPR.
In its simplest form, LamdaGen’s LSPR technology requires a light source and its nano-structured LSPR biochip. There is no need for adaptive elements to couple the light to the localized plasmons of the nano-structured surface. Among the broad spectrum of light, one wavelength resonantly couples to the localized plasmons on the biochip surface and is dominantly absorbed.
Therefore, the monitored reflected light plasmon has a minimum at this specific wavelength, called λmin. The value of λmin is dependent on the dielectric constant at the sensor surface. Changes at the surface as those induced by the binding of biomolecules or other substances, cause changes in the reflecting light including its λmin. These plasmonic changes are precisely monitored via spectroscopy and/or other optical methods including digital ones.
The binding of biomolecules on the LSPR active surface is captured by the spectrum of the reflected light and exhibits a slight red shift. The binding process is monitored in real-time.
LamdaGen has harnessed discoveries of complex LSPR, the principles of which involve advanced physics, optics and light and made simple their commercial application to detect and monitor biological and chemical interactions.