Enhance Your Protein Interaction Research with a New Level of Bench-Top Productivity
LamdaGen’s LightPath™ S4 system performs highly sensitive, label-free, real-time monitoring and analysis of biomolecular binding events. The S4 system integrates advanced optics, proprietary software and powerful nano-structured biosensors in a simple to use, flexible, and economical hands-on platform ideal for rapid assay development, kinetic profiling, sensitive protein quantitation and characterization of protein-ligand interaction.
Read More...Hide Detail Real-time, Label-free Detection
The Company's LSPR LightPath system coupled with its PEAK software precisely tracks the speed and strength of bind between bimolecules independent of labels.
Highly specific and sensitive binding interaction are continuously monitored by measuring the wavelength shift change of reflected light from the patented LSPR biosensors in direct proportion to surface binding events. The System's PEAK software tool captures all data while concurrently facilitating realtime sensorgram development during an assay. The result is an efficient and easy to use powerful system for generating valuable data and kinetics relative to the characterization of label-free binding events.
Read More...Hide Detail Affordable Gold Standard Results
The LightPath S-4 offers highly desirable label-free capability and more. LamdaGen's patented LSPR biosensors provide highly reproducible sensor-to-sensor and well-to-well sensitivity that meets or exceeds that of the industry's historic gold standard SPR platform. The LightPath S4 is a user friendly, plug & play, instrumentally simple system that is highly affordable in both purchase and annual operational cost. And if you desire femto-molar sensitivity you can also run in parallel an "OES" assay on the same chip as your direct label free assay.
Read More...Hide Detail High Reproducibility
LamdaGen's LSPR biosensors exhibit extraordinarily high reproducibility between individual sensors and also intra-sensor between individual sensor channels for both its P4 and P8 LSPR biochips (Figure 1 and Figure 2). Additionally, due to the robustness and of the Company's LSPR sensor manufacturing protocols, its instrumental simplicity and proprietary optics, reproducibility between instruments is also impressive.
Read More...Hide Detail High Sensitivity
LamdaGen's LSPR system is a powerful label-free solution for highly sensitive label-free molecular interaction analysis. The Company's products provide rich information re: recognition, binding and dissociation in real time. This information includes precise data on specificity, affinity, kinetic behavior and sample concentration. The Company's products are based upon the phenomenon of localized surface plasmon resonance (LSPR) and produce highly sensitive, affordable data that is equivalent to that of the leading SPR technology. LightPath also provides user friendly systems integrating several throughput options. Further, when integrating LamdaGen's LSPR proprietary OES system ultra-sensitivity into the femto-molar range becomes possible.
Read More...Hide Detail Crude Sample Compatibility
One of the fundamental differences between LSPR and SPR is the distance from the surface at which the respective plasmons can detect changes. While the penetration depth of the plasmon field for SPR is between 200-1000 nm, it is approximately 15-30 nm for LSPR. Hence, LSPR is far less susceptible to bulk effects occurring away from the surface. In other terms, LamdaGen’s LSPR detects changes very near the LSPR surface thereby allowing compatibility with complex or crude media.
Read More...Hide Detail Scalable for Throughput
LamdaGen’s LSPR sensors are a continuous metallic thin film which is characterized by a variety of unique physical, optical, and electrical properties that can be precisely controlled and tuned during manufacture for specific uses. These patented nano-structured films are “grown” on most any surface (glass-polymers-stainless-ceramic etc) and to nearly any size, shape or geometry, again depending on need or use. (For more information, go to LSPR FAQ!) Due to this flexibility, the Company’s robust sensors are also quite scalable. I.e. from 8 channels to 96 or more, examples of which are noted throughout the website.
Read More...Hide Detail Simple Data Acquisition and Analysis
The LamdaGen proprietary PEAK Software Suite is a highly robust 4th generation commercial software user interface that precisely and quite sensitively monitors and analyses. LamdaGen’s LSPR plasmon as it develops and evolves throughout a given assay or experiment. The user friendly and intuitive PEAK tool utilizes proprietary math functions in multiple and redundantly parallel ways to track and chart evolving real-time data as the size and character of the LamdaGen's LSPR plasmon evolves during assay. Due to the precision with which PEAK tracks its highly reproducible and robust LSPR plasmon in migration, PEAK’s raw data traces are typically more accurate than the highly manipulated end product data of traditional SPR systems.
