Plasmonics Research

FAQ

LamdaGen’s Electrochemical Sensing

Focus on Developing Electrochemical Sensors for Bio-analysis

  • LamdaGen’s patented nano-structured electrodes enable highly sensitive, real-time monitoring of biomolecular information
  • Potential targets in: Blood, Urine, Saliva, Perspiration, Interstitial Fluid

Attributes:

  • Low cost, simple instrumentation
  • Continuous monitoring
  • Highly selective and sub-pg/mL LOD
  • Fast response
  • Easy miniaturization
  • Ideal for mobile/wearable aps

Broad application:

  • Medical diagnostics
  • Personal health monitoring
  • Environmental pollution monitoring
  • Food toxin and drug detection
  • Industrial process monitoring
  • Agriculture nutrient & pollutant monitoring

 

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Flexible Sensing Membranes for Dermal-based Wearable Applications

The emerging wearable sensor market is forecast to reach $6B by 2026 (Research and Markets, 2016). Most of the existing wearable sensors are capable of monitoring physical parameters (e.g. heart rate, blood pressure, and temperature) but are unable to provide bio-chemical information. Perspiration analysis is a promising approach for noninvasive access to human biochemical information. For example, it has been used to diagnose cystic fibrosis and monitor drug levels, dehydration and muscle cramps. Perspiration carries rich biomarkers including1:

  • Electrolyte ions (Na+, Cl, K+, Ca2+, and NH4+)
  • Metabolites (lactate, creatinine, glucose, and uric acid)
  • Small molecules (ethanol, cortisol, urea, and Amino acids)
  • Small proteins (neuropeptides, cytokines and Interleukins)

The flexible properties of LamdaGen’s nanostructured sensors are ideal for enabling wearable sensing membranes for skin based health and wellness bio-sensing applications. The adaptive sensing membranes can be integrated into skin-contacting devices to analyze biomarkers in perspiration by a variety of detection methods such as electrical, optical, electrochemical and digital color imaging techniques. The sensors can also be fabricated in micron-scale size, allowing for the integration of a large number of sensor structures per unit area of flexible membrane. By enabling the miniaturization of wearable sensing devices the flexible systems are particularly well suited for building noninvasive diagnostic devices that simultaneously detect and monitor multiple biomarkers.

LamdaGen’s powerful sensing systems are being developed to provide actionable bio-rich health information at the surface of human skin for integration into wearable garments including head, arm and wrist bands, flexible dermal patches, and wearable health & fitness devices.

Other areas that LamdaGen is exploring for application of flexible nanostructured sensing membranes include:

  • Medical diagnostics
  • Food toxin and drug detection
  • Industrial process monitoring
  • Agriculture nutrient and pollutant monitoring

For details contact:  info@LamdaGen.com

1Sonner, Z. et al. Biomicrofluidics (2015)

LamdaGen nano-structured electrodes for multiple biomarkers

Micro-sized multiplex electrodes for multiple targets

LamdaGen electrochemical nano sensors for biomarker detection in sweat

Porous flexible sensing membrane

 

 

 

LamdaGen Electrochemical sensing, LSPR nanostructured sensor, cyclic voltammetry

Electrochemical sensing on LamdaGen’s nanostructured sensors

 

LamdaGen electrochemical sensors for perspiration biomarker detection in wearables

 
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Plasmonics Films

LamdaGen manufactures a variety of functional nanomaterials in the form of independent chips in common sizes and shapes for researchers who wish to work with a highly reproducible nano-structured metallic thin-film. These plasmonic films are not only exceedingly powerful, they also offer unparalled ease of use and economy.

In biological application the films are routinely used for highly sensitive biomolecular monitoring, drug discovery, and diagnostics. These homogeneous surfaces are also highly SERS active. Additional applications range from plasmonics to catalytics.

LamdaGen’s films can be precisely manufactured integrating a variety of noble metals, metal, metal oxides or combinations thereof, and reliably grown onto virtually any solid support including glass, polymers, ceramic and stainless steel.

LamdaGen’s approach for its nano-system assemblies are based upon the unique application properties required. Our use of precision grown nano-structures into functional materials containing optical, electrical and bio-sensing properties can be tailored or specifically designed to meet end user needs. The resulting metallic thin films are exceedingly robust and ideal for the investigation of energy transfer in optically active or catalytic systems which may have compelling potentials for the harvesting of light and other energy oriented applications.

 
LamdaGen’s nano-based LSPR biosensors can be easily configured for HTS.

Scalable for Throughput

LamdaGen’s LSPR sensors are a continuous metallic thin film which is characterized by a variety of unique physical, optical, and electrical properties that can be precisely controlled and tuned during manufacture for specific uses. These patented nano-structured films are “grown” on most any surface (glass-polymers-stainless-ceramic etc) and to nearly any size, shape or geometry, again depending on need or use. Due to this flexibility, the Company’s robust sensors are also quite scalable.

 

Frequently Asked Questions

FAQ: Can LamdaGen’s Functional Nano-Materials be used as nano-catalysts?

Yes. LamdaGen Corporation manufactures Functional Nano-Materials that are precisely organized, controlled and tuned for desired properties and application. The Company’s metallic thin-films can be specifically manufactured to perform catalytic processes. The adjacent graph is part of an early Meta-Catalytic Surface (MCS) data set. The data depicts the greatly enhanced and controlled reactivity of a simple H2O2 model comparing MCS to a traditional bulk catalyst of the same metal. LamdaGen’s MCS exhibits remarkable properties as a powerful catalyst for many reactions, including redox reactions.

LamdaGen manufactures functional nanomaterials that are proven capable of acting as powerful catalysts for various reactions, including redox ones.

FAQ: In what sizes, shapes, and dimensions can LamdaGen’s LSPR be manufactured?

Complementary to the ability to produce LSPR metallic thin films to be “grown” on almost any type of material, we also can “grow” in virtually any size, shape or dimension.  In fact, the films can be manufactured in large continuous sheets and later die cut and or twisted, turned or folded for specific commercial purposes.

This sort of flexibility is novel considering the powerful nature, robustness and high sensitivity of our LSPR sensor films, particularly when one begins to understand that the films can be used in non-bio ways as “dry-sensors”.

LamdaGens’s nano based catalytic LSPR grown on polymers for light sensing, photovoltaic and energy harvest.

FAQ: Can LamdaGen’s LSPR films be made using metals other than gold?

As mentioned elsewhere in the website, LamdaGen’s nano-structured thin-films can be precisely manufactured integrating a variety of noble metals, metal, metal oxides or combinations thereof- depending on the unique application required.